Parvovirus B19 infection is the cause of acute myeloid leukaemia

Abstract

Objectives.
Identifying a cause or the cause of acute myeloid leukaemia (AML) could be of help for the survival of
patients, while accelerating the diagnosis and therapy of AML.
Methods.
As known, a contingency table is defined by the fields a, b, c, d while a+b =U, c+d=U, a+c=W, b+d=W
and a+b+c+d = U+ U = W+W = N. Appropriate statistical methods like the necessary condition relationship,
defined as p(without Ut no Wt) = (a+b+d)/N, the sufficient condition relationship, defined as p(if Ut then Wt)
=(a+c+d)/N, the necessary and sufficient condition relationship, defined as p(Ut is necessary and sufficient for
Wt)=(a+d)/N, the exclusion relationship, defined as p(Ut excludes Wt) = (a)/N, and the causal relationship k,
defined as k(Ut,Wt)=σ (Ut,Wt)/(σ Ut)× σ Wt)), were used for causal data analysis. A p-value of less than 0.05
has been treated as significant.
Results.
Without parvovirus B19 infection, no acute myeloid leukaemia (P value = 0.0108). If parvovirus B19
infection, then acute myeloid leukaemia (Chi-square = 1.35 < 3.84). Parvovirus B19 infection is a necessary
and sufficient condition of acute myeloid leukaemia (Chi-square = 1.381 < 3.84). The causal relationship k
between a parvovirus B19 infection and acute myeloid leukaemia is highly significant (k = +0.7866, p Value
right tailed = 2.55351E-15).
Conclusion.
Thus far, until contrary evidence, according to this study it is justified to consider that parvovirus B19 is the
cause of acute myeloid leukaemia (p Value = 2.55351E-15).